Nathan E. Welty

     E-mail: welt0123@umn.edu

     Year Entered: 2008

     Degrees Received:
     Westmont College
     Chemistry and English majors
     B.S., 2008

     Honors Awarded:
     -Honors, Year 1, Medical School
     -Honors, Year 2, Medical School
     -Warren and Henrietta Warwick Fellowhip, 2012

     Thesis Advisor: Dan Kaplan, M.D., Ph.D.

     Thesis Research:
     The balance of intestinal immunity and tolerance is key in infection and
     autoimmunity, as well as in homeostatic responses to ingested antigen and commensal microbes. Lamina propria dendritic cells (lpDC) are antigen-presenting cells that reside below the intestinal epithelium and initiate adaptive immune responses to regulate this balance. There are several distinct subsets of lpDC, however the *in vivo* function of these subsets remains to be elucidated. Using transgenic mice in which we specifically target these subsets for deletion or genetic modification, my research aims to understand the subset-specific functions of lpDC in maintaining steady-state tolerance and in promoting immunity to pathogens.

Publications Prior to Entering MD/PhD Program:

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PRS, Agarwal A,  Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009;46:866-875.

Iles KE, Dickinson DA, Wigley AF, Welty NE, Blank V and Forman HJ. HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. Free Radic Biol Med. 2005;39:355-364.