Michael A. Weinreich

     E-mail: weinr010@umn.edu

     Year Entered: 2004

     Degrees Received:
     University of Washington
     Biology major
     B.S., 2001

     University of Minnesota
     Ph.D., 2010, Microbiology, Immunology and Cancer Biology PhD Program
     M.D., 2012, Medical School

Honors and Awards:
-J. Thomas Livermore Award for outstanding research in hematology, Minnesota Medical Foundation, 2007
-Doctoral Dissertation Fellowship, University of Minnesota Graduate School, 2009-2010

Thesis Advisor: Kristin Hogquist, Ph.D.

Thesis Research:
Our lab has identified Kruppel Like Factor 2 (KLF2) as a transcription factor necessary for T cell trafficking out of the thymus and into secondary lymphoid tissue.  I am working on the cellular signaling that controls KLF2 expression in the thymus. 

Publications (pubmed):

Weinreich MA, Jameson SC, Hogquist KA. Postselection Thymocyte Maturation and Emigration Are Independent of IL-7 and ERK5. J Immunol. 2011 Feb 1;186(3):1343-7.

Takada K, Wang X, Hart GT, Odumade OA, Weinreich MA, Hogquist KA, Jameson SC. Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol. 2011 Jan 15;186(2):775-83.

Weinreich MA, Odumade OA, Jameson SC, Hogquist KA. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol. 2010 Aug;11(8):709-16.

Odumade OA, Weinreich MA, Jameson SC, Hogquist KA. Kruppel-like Factor 2 Regulates Trafficking and Homeostasis of {gamma}{delta} T Cells. J Immunol. 2010 Jun 1;184(11):6060-6.

Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009;31:122-130.

Weinreich MA, Hogquist KA. Thymic emigration: when and how T cells leave home. J Immunol. 2008;181:2265-2270.

Hogquist KA, Weinreich MA, Jameson SC. Kruppeled T cells move again. Immunol Cell Biol. 2008;86:297-298.

Carlson CM, Endrizzi BT, Wu J, Ding X, Weinreich MA, Walsh ER, Wani M.A., Lingrel J.B., Hogquist K.A., Jameson S.C. Lung Kruppel-like factor regulates thymocyte and T cell migration. Nature 2006;442:299-302.

Publications Prior to Entering MD/PhD Program:

Weinreich MA, Lintmaer I, Wang L, Liggitt HD, Harkey MA, Blau CA. Growth factor receptors as regulators of hematopoiesis.Blood 2006;108:3713-1321.

Zhao S, Weinreich MA, Ihara K, Richard RE, Blau CA. In vivo selection of genetically modified erythroid cells using a Jak2-based cell growth switch. Mol Ther. 2004;10:456-468.

Richard RE, Weinreich M, Chang KH, Ieremia J, Stevenson M, Blau C. A. Modulating erythrocyte mixed Cchimerism in a mouse model of pyruvate kinase deficiency. Blood. 2004;103:4432-4439.

Ali M, Weinreich M, Balcaitis S, Cooper CJ, Fink PJ. Differential regulation of tolerance induced by deletion and TCR revision in VBeta5 transgenic mice. J Immunol. 2003; 171:6290-6296.