Mithun M. Shenoi


     Year Entered: 2004

     Degrees Received:
     Carnegie Mellon University
     Chemical and Biomedical Engineering majors
     B.S., 2004

     University of Minnesota
     Biomedical Engineering Graduate Program
     Ph.D., 2011

Thesis Advisor:   John Bischof, Ph.D.

Thesis Research:  Thermal ablation therapies are gaining increasing clinical acceptance for the treatment of focal malignancies in several organs including breast, kidney, liver, prostate and skin. Several technologies have been developed for the delivery of thermal energy to tumor tissues. These include radiofrequency ablation (RFA), cryoablation, high-intensity focused ultrasound (HIFU), microwaves, lasers, etc. Since most of these therapies are delivered in a minimally invasive manner, possible advantages of ablative therapies compared with surgical resection include the anticipated reduction in morbidity and mortality, low cost, suitability for real-time imaging guidance, ability to perform ablative procedures on an outpatient basis, and the potential application in a wider spectrum of patients-including those who are not surgical candidates.

Our lab is focussed on the use of TNF-alpha as a molecular adjuvant to enhance the efficacy of tumor destruction via thermal ablation. This has implications for reducing local recurrence and metastases as well as improving the imaging potential of the cryoablation technique. My work involves using imaging techniques to understand the tissue injury responses (coagulation, inflammation, wound healing) following thermal ablation. This work will be carried out in the context of comparing differences between high temperature and low temperature thermal ablation therapies.

Publications (pubmed):

Cressman EN, Geeslin MG, Shenoi MM, Hennings LJ, Zhang Y, Iaizzo PA, Bischof JC. Concentration and volume effects in thermochemical ablation in vivo: results in a porcine model. Int J Hyperthermia. 2012;28(2):113-21.

Cressman EN, Shenoi MM, Edelman TL, Geeslin MG, Hennings LJ, Zhang Y, Iaizzo PA, Bischof JC. In vivo comparison of simultaneous versus sequential injection technique for thermochemical ablation in a porcine model. Int J Hyperthermia. 2012;28(2):105-12.

Shenoi MM, Shah NB, Griffin RJ, Vercellotti GM, Bischof JC. Nanoparticle preconditioning for enhanced thermal therapies in cancer. Nanomedicine (Lond). 2011 Apr;6(3):545-63.

Pedro RN, Thekke-Adiyat T, Goel R, Shenoi M, Slaton J, Schmechel S, Bischof J, Anderson JK. Use of Tumor Necrosis Factor-Alpha-coated Gold Nanoparticles to enhance radiofrequency ablation in a translational model of renal tumors. Urology. 2010 Aug;76(2):494-8.

Venkatasubramanian RT, Wolkers WF, Shenoi MM, Barocas VH, Lafontaine D, Soule CL, Iaizzo PA, Bischof JC. Freeze-thaw induced biomechanical changes in arteries: Role of collagen matrix and smooth muscle cells. Ann Biomed Eng. 2010;38:694-706.

Shenoi MM, Anderson J, Bischof JC. Nanoparticle enhanced thermal therapies. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1979-1982.

Kim S-J, Shenoi M, Yoo K, Shim J, Chung W, Ko C, Kim L-S, Yoon E. Label-free CMOS DNA quantification with on-chip noise reduction schemes. Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International Volume:947­-950.