Oludare Odumade

 

     E-mail: oduma002@umn.edu

     Year Entered: 2007

     Degrees Received:
     Hamline University
     Biology and Psychology majors
     B.A., 2003

     University of Minnesota
     Microbiology, Immunology, Cancer Biology Ph.D. Program
     Ph.D., 2011

     Honors and Awards:
     -
Ruth L. Kirschstein National Research Service Award for Predoctoral
     MD/PhD Fellows, National Institute of Allergy and Infectious Disease,
     2009-2011
-Minnesota Medical Foundation's Beatrice Z. Milne and Theodore Brandenburg Award and J. Jacob Kaplan Award, 2011

Thesis Advisor: Kristin Hogquist, Ph.D.

Thesis Research: My work in the Hogquist lab focuses on T-cell development and on the immunological mechanisms that control the T cell repertoire and lead to an effective adaptive immune response.

We are currently characterizing the way in which CD8+ T cells together with other signals (i.e. cytokine signals) influence the development EBV-induced diseases. Epstein-Barr virus (EBV), a gamma-herpes virus, is one of the most common infectious human viruses worldwide. Infection in early childhood is common and usually asymptomatic while infection during the second decade or later often causes infectious mononucleosis (IM). IM is characterized by fever, hepatosplenomegaly, pharyngitis, lymphadenopathy and atypical lymphocytosis. Furthermore, EBV has been associated with many types of cancer such as Burkitt's lymphoma and can cause serious complications. This work seeks to reduce gaps in knowledge as to the underlying immunological mechanisms that occur during EBV infection and facilitate efforts to develop a vaccine that protects from IM and/or EBV-related sequelae.

Another component of our work focuses on the role of a transcription factor, LKLF (KLF-2) on thymic emigration of mature T cells. Previous research indicates that KLF-2 may be critical T cell homeostasis and survival in view of the fact that KLF-2 deficiency results in reduced mature single positive lymphocytes in the lymph node and spleen. As KLF-2 knockout mice are embryonic lethal due to defects in vasculogenesis, our lab as created a conditional KLF-2 knockout. We aim to elucidate the role of the transcription factor KLF-2 in the development and thymic emigration of non-conventional T cells, such as regulatory T cells (CD4+ CD25+ Foxp3+), gamma-delta T cells, and Natural Killer-T cells. Understanding what factors control the migration of T cells will allow the development of specific immunomodulatory drugs for use in autoimmunity, inflammatory diseases and transplant immunity.

Publications (pubmed):

Balfour HH Jr, Odumade OA, Schmeling DO, Mullan BD, Ed JA, Knight JA, Vezina HE, Thomas W, Hogquist KA. Behavioral, Virologic, and Immunologic Factors Associated with Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students. J Infect Dis. 2012 Oct 24. [Epub ahead of print]

Odumade OA, Knight JA, Schmeling DO, Masopust D, Balfour HH Jr, Hogquist KA. Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans. J Exp Med. 2012 Mar 12;209(3):471-8.

Odumade OA, Hogquist KA, Balfour HH Jr. Progress and problems in understanding and managing primary epstein-barr virus infections. Clin Microbiol Rev. 2011 Jan;24(1):193-209.

Takada K, Wang X, Hart GT, Odumade OA, Weinreich MA, Hogquist KA, Jameson SC. Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol. 2011 Jan 15;186(2):775-83.

Lowman XH, McDonnell MA, Kosloske A, Odumade OA, Jenness C, Karim CB, Jemmerson R, Kelekar A. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol Cell. 2010 Dec 10;40(5):823-33.

Weinreich MA, Odumade OA, Jameson SC, Hogquist KA. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol. 2010 Aug;11(8):709-16.

Odumade OA, Weinreich MA, Jameson SC, Hogquist KA. Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J Immunol. 2010 Jun 1;184(11):6060-6.

Publications prior to entering the MD/PhD Program:

Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA, Rose NR. A novel model of drug hapten-induced hepatitis with increased mast cells in the BALB/c mouse. Exp Mol Pathol. 2005;78:87-100.

Mayerova D, Parke EA, Bursch LS, Odumade OA, Hogquist KA. Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state. Immunity. 2004;21:391-400.