David Lin

     E-mail: linxx102@umn.edu

     Year Entered: 2005

     Degrees Received:
     University of Minnesota
     Biochemistry, Genetics, Cell Biology and Development major
     B.S.,  2005

     University of Minnesota
     Pharmacology Graduate Program
     Ph.D., 2012

     Honors and Awards:
     -Honors, Years 1 and 2, Medical School

     Thesis Advisor: Horace Loh, Ph.D.

     Thesis Research: Opioid receptors are G protein coupled receptors, and they are divided into three classes: mu, delta, and kappa.  Among them, the mu opioid receptor (MOR) is responsible for the analgesic, physical dependence, and reward effects of opiates such as morphine.  After agonist stimulation, the internalization and trafficking of opioid receptors are important mechanisms to regulate its signaling.  Using mass spectrometry, the Loh lab has identified Rab40b as a binding partner of MOR.  Rab proteins are small molecular weight GTPases that are important in cellular membrane trafficking.  Rab40b contains a SOCS box, but the protein’s functions are not well known.  I am using a combination of cell and molecular biology tools to study the function of Rab40b.  We would like to know how Rab40b regulates opioid receptor signaling.

Publications (pubmed):

Wu Q, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim DK, Law PY, Loh HH, Wei LN. MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J. 2012 Oct 19. [Epub ahead of print]

Lin HY, Law PY, Loh HH. Activation of PKCα or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdose. J Pharmacol Exp Ther. 2012 Apr;341(1):115-25.