David A. Knorr

     E-mail: knorr013@umn.edu

     Year Entered: 2007

     Degrees Received:
     University of North Dakota
     Interdisciplinary Studies-Health Sciences
     B.S., 2007

     University of Minnesota
     Microbiology, Immunology and Cancer Biology
     Ph.D., 2012

     Honors and Awards:
     -2002-07 Dean’s List, University of North Dakota
     -2002-07 Presidential Scholar, University of North Dakota
     -2002 Student Government Scholar
     -2005-06 North Dakota Advanced Undergraduate Research Award
     -2007 Graduated Summa Cum Laude
                                                                               -2011 ASH Abstract Achievement Award
                                                                               -2012 Doctoral Dissertation Fellowship
                                                                               -2012 F&T Pilot Grant

Thesis Advisor: Dan Kaufman, M.D., Ph.D.

Thesis Research: My work focuses on the development of lymphocytes from different populations of human stem cells. These include hematopoietic stem cells (HSCs) as well as human embryonic and induced pluripotent stem cells. Use of each of these starting populations provides a reliable in vitro system to study human lymphocyte development. In contrast to HSCs, the use of hESC- and iPSC-derived hematopoietic progenitors provides a genetically tractable system to study the molecular mechanisms driving human lymphocyte development into T, B, or NK cells.

Kaufman lab web site.

Publications (pubmed):

Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms. J Virol. 2011 Jan;85(1):43-50.

Knorr DA, Kaufman DS. Pluripotent stem cell-derived natural killer cells for cancer therapy. Transl Res. 2010 Sept;156(3):147-154.

Woll PS, Grzywacz B, Tian X,  Marcus R, Knorr DA,Verneris MR, Kaufman DS. Human embryonic stem cells differentiate into a unique population of natural killer cells with highly potent in vivo anti-tumor activity. Blood. 2009 Jun 11;113(24):6094-101.

Abstracts:

Gawryluk JW, Knorr DA, Bough KJ,Wethering J, Dingledine RJ,  Geiger JD. Ketogenic diet increase seizure threshold and levels of high-energy brain metabolites in rat. American Society of Neurochemistry 36th Annual Meeting, Madison, WI, July 2005.

Knorr DA,  Johnson W, Johnson-McCullar V, Miller J. Optimization of an in vitro assay measuring NK cell proliferation using alamar blue in high throughput screening. University of Minnesota Medical School 7th Annual Research Day, Minneapolis, MN, March 2008.

Knorr DA,Ni Z, Woll P,  Kaufman DS. Development of lymphocytes from human pluripotent stem cells. University of Minnesota Medical School 8th Annual Research Day, Minneapolis, MN, March 2009.

Publications Prior to Entering MD/PhD Program:

Wheeler D, Knapp E, Bandaru VVR, Wang Y,  Knorr D, Poirier C, Mattson MP, Geiger JD,Haughey NJ. Tumor necrosis factor-Éø-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem. 2009. (Epub ahead of print)

Szklarczyk A, Ewaleifoh O, Beique JC, Wang Y, Knorr D, Haughey N, Malpica T, Mattson MP, Huganir R, Conant K. MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function. FASEB J. 2008 ;22:3757-3767.