Samuel W. Cramer


     Year Entered: 2008

     Degrees Received:
     University of Wisconsin, Madison
     Molecular Biology major
     B.S., 2008

     Honors and Awards:
     -Honors, Years 1 and 2, Medical School
     -Morris Smithberg Memorial Prize for outstanding performance by a
     first-year neuroscience graduate student, University of Minnesota,
     -University of Minnesota Milne-Brandenburg Award, 2011

     Thesis Advisor: Timothy Ebner, M.D., Ph.D.

     Thesis Research: The goal of my thesis research is to further the understanding of cerebellar physiology. Specifically, my work focuses on investigating the way in which information is spatially represented and integrated into the cerebellar circuitry.  In pursuit of this goal, I employ techniques including autofluorescence and calcium dye optical imaging as well as electrophysiology and optogenetics, all of which are performed in vivo.

Publications (pubmed):

Ebner TJ, Wang X, Gao W, Cramer SW, Chen G. Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity. Cerebellum. 2012 Jun;11(2):418-9. 

Publications Prior to Entering MD/PhD Program:

Begum G, Kintner D, Liu Y, Cramer SW, Sun D. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem. 2012 Feb;120(4):622-30.

Cramer SW, Baggott C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D. The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Mol Pain. 2008 Sep 17;4:36.

Wang Y, Luo J, Chen X, Chen H, Cramer SW, Sun D. Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. Eur J Neurosci. 2008 ;28:51-61.

Luo J, Wang Y, Chen H, Kintner DB, Cramer SW, Gerdts JK, Chen X, Shull GE, Philipson KD, Sun D. A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. J Cereb Blood Flow Metab. 2008 28:737-746.